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DNA Nucleolin

DNA LaminB1

What is truly remarkable about toroidal nuclei is the fact that they harbor cytosolic components within their void such as actin fibers, microbutules or even lysosomes.

Toroidal nuclei, with their captivating ring-like shape, offer a window into the complex world of cellular architecture

Unlike nuclear invaginations, toroidal nuclei maintain a conventional nuclear envelope surrounding their DNA, a fact confirmed by LaminB1 staining.

The unique structure of toroidal nuclei sets them apart from any familiar nuclear component. By employing staining methods that target nucleoli-specific markers like UBF and Nucleolin, it becomes apparent that these nuclei do not resemble enlarged nucleoli.

Our Imaris 3D image reconstitution, reveals the true nature of toroidal nuclei. Watch as DNA, depicted in blue, forms distinct ring-like shapes, while vibrant yellow dots represent lysosomes within the void. Our captivating visuals dispel any notion of nuclear invagination or image artifact, offering an insightful glimpse into the intricate cellular organization.

DNA Lysosomes

DNA Microtubules

The Toroidal nucleus sheds light on a unique connection between the nucleus and the surrounding cytoplasm, offering new insights into intracellular organization

DNA Actin Fibers

Join us for an eye-opening journey into the inner workings of your cells as we explore the crucial role of autophagy and lysosomes in safeguarding your genetic blueprint!

In this captivating video, we explain our latest findings showing how these cellular heroes help to maintain the stability of your DNA. Don't miss out on this fascinating insight into the hidden world of cellular biology.